Alliance for Pandemic Preparedness

April 19, 2021

Reduced Humoral Response to MRNA SARS‐Cov‐2 BNT162b2 Vaccine in Kidney Transplant Recipients without Prior Exposure to the Virus

Category:

Topic:

Keywords (Tags):

  • Few kidney transplant recipients (51/136, 38.5%) who had been fully vaccinated with the Pfizer-BioNTech vaccine developed a positive response to the SARS-CoV-2 spike protein, suggesting that this population may remain at risk of infection despite vaccination. Compared to controls, mean IgG anti‐spike levels were lower (31.05 vs 200.5 AU/mL). Older age (OR = 1.7), use of high dose corticosteroids in the last 12 months (OR = 1.3), and a treatment regimen that included mycophenolate (OR = 1.5) were associated with negative serology.

Grupper et al. (Apr 18, 2021). Reduced Humoral Response to MRNA SARS‐Cov‐2 BNT162b2 Vaccine in Kidney Transplant Recipients without Prior Exposure to the Virus. American Journal of Transplantation. https://doi.org/10.1111/ajt.16615