Alliance for Pandemic Preparedness

April 20, 2021

The Increase in the Risk of Severity and Fatality Rate of Covid-19 in Southern Brazil after the Emergence of the Variant of Concern (VOC) SARS-CoV-2 P.1 Was Greater among Young Adults without Pre-Existing Risk Conditions

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  • [Pre-print, not peer-reviewed] A higher proportion of younger patients (age <60 years) were observed among severe COVID-19 cases leading to death (28%) in the second wave in Brazil (February 2021) as compared to the first wave (18%) (November-December 2020). This second wave was predominantly the P.1 variant. Similarly, a higher proportion of patients without pre-existing conditions was present among severe COVID-19 cases (22% vs 13%). While the case fatality rate (CFR) increased for all age groups between the first and second wave, females aged 20-39 years with no pre-existing conditions had a 5.6-fold higher CFR during the second vs first wave and individuals aged 40-59 years had a 7.7-fold higher CFR.

Freitas et al. (Apr 19, 2021). The Increase in the Risk of Severity and Fatality Rate of Covid-19 in Southern Brazil after the Emergence of the Variant of Concern (VOC) SARS-CoV-2 P.1 Was Greater among Young Adults without Pre-Existing Risk Conditions. Pre-print downloaded Apr 20 from https://doi.org/10.1101/2021.04.13.21255281