Alliance for Pandemic Preparedness

April 22, 2021

Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates from Pennsylvania

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  • [Pre-print, not peer-reviewed] A SARS-CoV-2 B.1.1.7 sequence from Pennsylvania detected in March 2021 was found to have the E484K spike substitution, a mutation shown to confer resistance to neutralizing antibodies. Only 60 isolates with the B.1.1.7+E484K sequence profile have been detected in the US, and only 253 reported globally. Comparative genomic analysis of 235 high coverage genomes suggests at least 7 independent acquisitions of the E484K substitution by the B.1.1.7 lineage.

Ahmed et al. (Apr 21, 2021). Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates from Pennsylvania. Pre-print downloaded Apr 22 from https://www.biorxiv.org/content/10.1101/2021.04.21.440801v1.full.pdf