Alliance for Pandemic Preparedness

April 23, 2021

Previous COVID-19 Infection but Not Long-COVID Is Associated with Increased Adverse Events Following BNT162b2Pfizer Vaccination

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  • [Pre-print, not peer-reviewed] A study of UK healthcare workers (N=974) vaccinated with the Pfizer-BioNTech vaccine found that prior SARS-CoV-2 infection, but not long-COVID, was associated with a higher incidence of self-reported adverse events following the first vaccine dose. Those with a self-reported prior SARS-CoV-2 infection were more likely to report ≥1 moderate-to-severe symptom with onset 24-48 hours post-vaccination (56% vs. 47%). The most commonly reported symptoms were fever, fatigue, muscle and joint pain, and swollen lymph nodes. Adverse events were more common in women and decreased with age. Adverse events were not statistically more common among the small subset of persons with long-COVID (N=30) compared to those without long-COVID.

Raw et al. (Apr 22, 2021). Previous COVID-19 Infection but Not Long-COVID Is Associated with Increased Adverse Events Following BNT162b2Pfizer Vaccination. Pre-print downloaded Apr 23 from https://doi.org/10.1101/2021.04.15.21252192