April 23, 2021

Real World Effectiveness of COVID-19 mRNA Vaccines against Hospitalizations and Deaths in the United States

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): vaccine

• [Pre-print, not peer-reviewed] A large, retrospective cohort analysis of patients enrolled in a Houston, TX healthcare network (N=91,134) found that vaccination with 2 doses of either the Pfizer-BioNTech or Moderna vaccine reduced the risk of COVID-19 hospitalization by 96% and COVID-19 associated deaths by 99%. Additionally, the study found that persons with partial immunization, (defined as 2 weeks following the 1st dose through 7 days following the 2nd dose) had a 77% lower risk of hospitalization and a 64% lower risk of death. Effectiveness did not differ significantly across populations defined by age, race/ethnicity, area deprivation index, or comorbidities. The authors note that this is the largest cohort vaccine effectiveness study in a US population published to date.

Vahidy et al. (Apr 23, 2021). Real World Effectiveness of COVID-19 mRNA Vaccines against Hospitalizations and Deaths in the United States. Pre-print downloaded Apr 23 from https://doi.org/10.1101/2021.04.21.21255873