April 26, 2021

Asymptomatic and Symptomatic SARS-CoV-2 Infections Elicit Polyfunctional Antibodies

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity

• Cellular assays evaluating antibody-dependent cellular cytotoxicity (ADCC) combined with assessments of antibody titers and neutralization activity indicated that asymptomatic infection with SARS-CoV-2 induces a polyfunctional antibody response. In this study, antibody responses were slightly lower among asymptomatic than symptomatic individuals, but did not differ in neutralization activity or the ability to trigger ADCC and complement deposition.

Dufloo et al. (Apr 2021). Asymptomatic and Symptomatic SARS-CoV-2 Infections Elicit Polyfunctional Antibodies. Cell Reports. Medicine. https://www.sciencedirect.com/science/article/pii/S2666379121001038h