Alliance for Pandemic Preparedness

April 26, 2021

Cerebral Venous Sinus Thrombosis (CVST) Is Not Significantly Linked to COVID-19 Vaccines or Non-COVID Vaccines in a Large Multi-State US Health System

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  • [Pre-print, not peer-reviewed] Cerebral venous sinus thrombosis (CVST), which occurs when a blood clot prevents blood from properly flowing out of the brain, was rare and not significantly associated with COVID-19 vaccines in a study conducted among individuals who received the Pfizer-BioNTech (n = 94,818 doses), Moderna (n = 36,350 doses) and Johnson & Johnson vaccines (n = 1,745 doses), as well as those who received one of 10 FDA-approved non-COVID-19 vaccines (n = 771,805 doses) at the Mayo Clinic hospital system between January 1, 2017 and March 15, 2021. 3 cases of CVST were observed within the 30 days following Pfizer-BioNTech vaccination (2 females, 1 male; ages 79, 80, 84), including one individual with a prior history of thrombosis and another with trauma in the past 30 days. No cases of CVST were observed among the patients receiving Moderna or Johnson & Johnson vaccines. 

Pawlowski et al. (Apr 23, 2021). Cerebral Venous Sinus Thrombosis (CVST) Is Not Significantly Linked to COVID-19 Vaccines or Non-COVID Vaccines in a Large Multi-State US Health System. Pre-print downloaded Apr 26 from https://doi.org/10.1101/2021.04.20.21255806