April 27, 2021

Effectiveness of MRNA COVID-19 Vaccines against SARS-CoV-2 Infection in a Cohort of Healthcare Personnel

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): vaccine breakthrough, vaccine efficacy

• The COVID-19 mRNA vaccines were up to 96% effective in preventing PCR-confirmed SARS-CoV-2 infection following two doses, according a retrospective cohort study of over 45,000 US healthcare personnel. The Pfizer-BioNTech vaccine accounted for 93% of vaccinations and the Moderna vaccine accounted for 7%. The authors adjusted for age, gender, region, job, and week of vaccination in their analysis. Vaccine effectiveness was 78% among those receiving only one dose (n>4,000).

Swift et al. (Apr 26, 2021). Effectiveness of MRNA COVID-19 Vaccines against SARS-CoV-2 Infection in a Cohort of Healthcare Personnel. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciab361