April 29, 2021

Prothrombotic Immune Thrombocytopenia after COVID-19 Vaccine

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): adverse effects, vaccines

• 5 cases of prothrombotic immune thrombocytopenia were identified in Germany at 5 to 11 days after receiving the first dose of the Oxford-AstraZeneca vaccine. Clinical manifestations included cerebral venous sinus thrombosis, splanchnic vein thrombosis, arterial cerebral thromboembolism, and thrombotic microangiopathy. Anti-PF4/polyanion antibodies were detected in all patients. After anticoagulation alone or in combination with eculizumab or intravenous immunoglobulin, thromboembolic events resolved in three patients but persisted in two patients.

Tiede et al. (Apr 28, 2021). Prothrombotic Immune Thrombocytopenia after COVID-19 Vaccine. Blood. https://doi.org/10.1182/blood.2021011958