Alliance for Pandemic Preparedness

April 29, 2021

Prothrombotic Immune Thrombocytopenia after COVID-19 Vaccine



Keywords (Tags): ,

  • 5 cases of prothrombotic immune thrombocytopenia were identified in Germany at 5 to 11 days after receiving the first dose of the Oxford-AstraZeneca vaccine. Clinical manifestations included cerebral venous sinus thrombosis, splanchnic vein thrombosis, arterial cerebral thromboembolism, and thrombotic microangiopathy. Anti-PF4/polyanion antibodies were detected in all patients. After anticoagulation alone or in combination with eculizumab or intravenous immunoglobulin, thromboembolic events resolved in three patients but persisted in two patients.

Tiede et al. (Apr 28, 2021). Prothrombotic Immune Thrombocytopenia after COVID-19 Vaccine. Blood.