April 30, 2021

Factors Influencing the Efficacy of COVID-19 Vaccines: A Quantitative Synthesis of Phase III Trials

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): vaccines

• A meta-analysis of efficacy data from Phase III trials of the Pfizer-BioNTech, Moderna, AstraZeneca, and Sputnik V vaccines found that type of vaccine, age and sex of recipients, and the underlying rate of COVID-19 in the study populations did not affect vaccine efficacy. The meta-regression calculated lower efficacy point estimates for the mRNA vaccines among older age groups without a statistically significant test for effect modification. 

Calzetta et al. (Apr 1, 2021). Factors Influencing the Efficacy of COVID-19 Vaccines: A Quantitative Synthesis of Phase III Trials. Vaccines. https://doi.org/10.3390/vaccines9040341