Alliance for Pandemic Preparedness

April 30, 2021

Head-to-Head Evaluation of Five Automated SARS-CoV-2 Serology Immunoassays in Various Prevalence Settings

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  • A comparison of five automated SARS-CoV-2 serology tests found that the Euroimmun and Roche assays (either the assay targeting the nucleocapsid (N) or spike protein (S) antigens) performed equally well without the need for additional confirmatory testing in high prevalence settings compared to the gold standard of rRT-PCR and rIFA. However, the authors suggest that in lower prevalence settings, combining assays that detect antibodies to N- and S-antigens may be needed.

Andrey et al. (Apr 10, 2021). Head-to-Head Evaluation of Five Automated SARS-CoV-2 Serology Immunoassays in Various Prevalence Settings. Journal of Clinical Medicine. https://doi.org/10.3390/jcm10081605