April 30, 2021

SARS-CoV-2 Seroprevalence, and IgG Concentration and Pseudovirus Neutralising Antibody Titres after Infection, Compared by HIV Status: A Matched Case-Control Observational Study

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

Keywords (Tags): clinical characteristics

• Persons living with HIV had lower SARS-CoV-2 IgG seroprevalence (3.7%) compared to persons without HIV (7.4%), according to a retrospective matched case-control study (N=2,200) of remnant serum samples from US adults presenting for routine laboratory testing. However, among those who had past SARS-CoV-2 infection, persons living with HIV were more likely to have had severe COVID-19 (OR = 5.5) and have lower IgG concentrations and pseudovirus neutralizing antibody titers, indicating a diminished immunological response. 

Spinelli et al. (Apr 30, 2021). SARS-CoV-2 Seroprevalence, and IgG Concentration and Pseudovirus Neutralising Antibody Titres after Infection, Compared by HIV Status: A Matched Case-Control Observational Study. The Lancet HIV. https://doi.org/10.1016/S2352-3018(21)00072-2