Alliance for Pandemic Preparedness

April 30, 2021

The Impact on Infectivity and Neutralization Efficiency of SARS-CoV-2 Lineage B.1.351 Pseudovirus

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  • An in-vitro comparison of SARS-CoV-2 spike pseudoviruses carrying mutations characteristic of the B.1.351 lineage (N501Y, K417N, and E484K) and the original D614G lineage found that the viruses in the B.1.351 lineage demonstrated increased infectivity in cellular assays. Additionally, the monoclonal antibody imdevimab neutralized all three B.1.351 lineage viruses, while neutralization by the monoclonal antibody casirivimab was significantly reduced.

Kim et al. (Apr 7, 2021). The Impact on Infectivity and Neutralization Efficiency of SARS-CoV-2 Lineage B.1.351 Pseudovirus. Viruses. https://doi.org/10.3390/v13040633