May 3, 2021

SARS-CoV-2 Antibodies Remain Detectable 12 Months after Infection and Antibody Magnitude Is Associated with Age and COVID-19 Severity

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immune response

• [Pre-print, not peer-reviewed] An analysis of longitudinal serum samples collected from U.S. active duty service members, dependents, and military retirees with PCR-confirmed SARS-CoV-2 infection between March 2020 and March 2021 found 100% seropositivity among inpatients followed for six months (58/58) to one year (8/8). Seroreversion was observed in 5% (9/192) of outpatients six to ten months after symptom onset, and 18% (2/11) of outpatients followed for one year. In both groups, the half-life of anti-SARS-CoV-2 binding-IgG responses was >1000 days post-symptom onset. Older age was positively correlated with both higher IgG binding and neutralizing antibody levels, after controlling for COVID-19 hospitalization status. 

Laing et al. (May 2, 2021). SARS-CoV-2 Antibodies Remain Detectable 12 Months after Infection and Antibody Magnitude Is Associated with Age and COVID-19 Severity. Pre-print downloaded May 3 from https://doi.org/10.1101/2021.04.27.21256207