Alliance for Pandemic Preparedness

May 3, 2021

SARS-CoV-2 Worldwide Replication Drives Rapid Rise and Selection of Mutations across the Viral Genome: A Time-Course Study – Potential Challenge for Vaccines and Therapies

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  • A summary of circulating SARS-CoV-2 mutations in 383,570 complete sequences with known sampling dates in the Global Initiative of Sharing All Influenza Data (GISAID) through April 5, 2021 showed that high incidence of COVID-19 often paralleled high numbers of new mutations and SARS-CoV-2 variant strains. The summary included data from ten countries: the United Kingdom, South  Africa, Brazil, USA, India, Russia, France, Spain, Germany, and China. Among approximately 180 novel mutations, some previously reported mutations waned and some increased in prevalence over time, including the B.1.1.7 and B.1.351, and P.1 and P.2 variants.

Weber et al. (May 2021). SARS-CoV-2 Worldwide Replication Drives Rapid Rise and Selection of Mutations across the Viral Genome: A Time-Course Study – Potential Challenge for Vaccines and Therapies. EMBO Molecular Medicine. https://doi.org/10.15252/emmm.202114062