Alliance for Pandemic Preparedness

May 3, 2021

US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021

Category:

Topic:

Keywords (Tags):

  • A case series of 12 patients in the US who experienced cerebral venous sinus thrombosis (CVST) with thrombocytopenia following the Johnson & Johnson/Janssen vaccine found that all patients were women under the age of 60 who began experiencing symptoms that required hospitalization between 6 and 15 days after vaccination. Seven patients had at least 1 CVST risk factor, including obesity (n = 6), hypothyroidism (n = 1), and oral contraceptive use (n = 1). Among 11 patients tested for heparin-induced thrombocytopenia (HIT) antibodies, all were positive, and none had documented prior heparin exposure. As of April 12, 2021, reported outcomes were death (n = 3), intensive care unit (ICU) care (n = 3), non-ICU hospitalization (n = 2), and discharge to home (n = 4).

See et al. (Apr 2021). US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021. JAMA. https://doi.org/10.1001/jama.2021.7517