Alliance for Pandemic Preparedness

May 4, 2021

SARS -CoV-2 T-Cell Immunity to Variants of Concern Following Vaccination



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  • [Pre-print, not peer-reviewed] A study using two standardized, functional assays to measure memory T cell immunity to SARS-CoV-2 found that individuals vaccinated with the COVID-19 mRNA vaccines (n=29) mounted a more robust T cell response than convalescent patients (n=19) or healthy controls with no prior infection (n=25). The assay was based upon the “Quantiferon Gold” test for tuberculosis and measured secreted interferon gamma. T cell responses among vaccinated individuals to variants of concern B.1.1.7, B.1.351, and B.1.1.248 were detected but diminished, with median responses lower though not statistically significant among those receiving the Pfizer-BioNTech vaccine than the Moderna vaccine.

Gallagher et al. (May 3, 2021). SARS -CoV-2 T-Cell Immunity to Variants of Concern Following Vaccination. Pre-print downloaded May 4 from