Alliance for Pandemic Preparedness

May 5, 2021

A High-Throughput Microfluidic Nanoimmunoassay for Detecting Anti–SARS-CoV-2 Antibodies in Serum or Ultralow-Volume Blood Samples

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  • A microfluidic nanoimmunoassay to detect anti-SARS-CoV-2 IgG antibodies achieved a sensitivity of 98% and specificity of 100% based on an analysis of 134 pre-pandemic sera and 155 sera from PCR-confirmed individuals. The assay relies on a repurposed blood from a glucose test strip (finger prick) and other low-cost blood sampling methods to eliminate the need for venipuncture, and is capable of analyzing up to 1,024 samples per device.

Swank et al. (May 4, 2021). A High-Throughput Microfluidic Nanoimmunoassay for Detecting Anti–SARS-CoV-2 Antibodies in Serum or Ultralow-Volume Blood Samples. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2025289118