May 10, 2021

Progressive and Parallel Decline of Humoral and T Cell Immunity in Convalescent Health Care Workers with Asymptomatic or Mild-Moderate SARS-CoV-2 Infection

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity

• Among healthcare workers in Spain who recovered from COVID-19 (n = 22), T-cell response was significantly lower among those with early loss of antibodies (6 cases, 27%) a median of 1.8 months after diagnosis. After 5.1 months, 77% of participants had antibody decline (41% seroreverted; p<0.01), and 36% lost T-cell response (75% lost response to spike protein). 

Casado et al. (May 7, 2021). Progressive and Parallel Decline of Humoral and T Cell Immunity in Convalescent Health Care Workers with Asymptomatic or Mild-Moderate SARS-CoV-2 Infection. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiab242