Alliance for Pandemic Preparedness

May 10, 2021

Short-Term Effects of BNT162b2 MRNA COVID-19 Vaccination on Physiological Measures a Prospective Study

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  • [Pre-print, not peer-reviewed] A prospective study of adults (n = 160) in Israel who had not been previously infected with SARS-CoV-2 evaluated physiological changes in participants before and after their second Pfizer-BioNTech dose. Participants were given a chest-patch sensor to wear for four days, starting one day before vaccination. The sensor measured 13 physiological parameters including heart rate, blood oxygen saturation, respiratory rate, blood pressure, cardiac output, and body temperature, and the accompanying mobile application collected daily self-reported questionnaires regarding local and systemic reactions, sleep quality, stress levels, physical activity, and mood levels. Within the first 48 hours post-vaccination, there were significant changes in nearly all 13 chest-patch indicators compared to baseline, including among 78 participants (half of the cohort) who reported no local or systemic reactions. These measures returned to baseline levels within three days after vaccination.

Gepner et al. (May 7, 2021). Short-Term Effects of BNT162b2 MRNA COVID-19 Vaccination on Physiological Measures a Prospective Study. Pre-print downloaded May 10 from https://doi.org/10.1101/2021.05.06.21256587