Alliance for Pandemic Preparedness

May 13, 2021

Neutralization Potential of Covishield Vaccinated Individuals against B.1.617.1

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  • [Pre-print, not peer-reviewed] Individuals with prior SARS-CoV-2 infection (n=18) had 24-fold higher levels of anti-SARS-CoV-2 neutralizing antibodies (nAbs) against the B.1.617.1 variant, which is linked to recent surges in cases in India, 4 weeks after the second dose of the Covishield vaccine (Oxford-AstraZeneca vaccine version manufactured in India), compared to those without a previous history of infection (n=43). Geometric mean titers (GMTs) for nAbs against the D614G variant among vaccinated individuals with prior infection were also 30-fold higher than vaccinated individuals without prior infection. Among vaccinated individuals without prior infection, neutralization titers against the B.1.617.1 variant were reduced 2-fold compared to those against the D614G variant .

Yadav et al. (May 12, 2021). Neutralization Potential of Covishield Vaccinated Individuals against B.1.617.1. Pre-print downloaded May 13 from https://doi.org/10.1101/2021.05.12.443645