Alliance for Pandemic Preparedness

May 17, 2021

Cellular Immunity Predominates over Humoral Immunity after the First Dose of COVID-19 Vaccines in Solid Organ Transplant Recipients

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  • [Pre-print, not peer-reviewed] Among solid organ transplant recipients (n = 40) and age-matched controls (n = 70), antibodies were detected in only 5% of transplant recipients versus 80% of controls, though specific CD4 and/or CD8 T-cells were more frequently found in both transplant recipients (24%) and controls (84%). IgG and neutralization activity were also higher after vaccination with one of the mRNA vaccines compared to the Oxford-AstraZeneca vaccine, while CD4 and CD8 T-cell levels were higher after the Oxford-AstraZeneca vaccine. The authors suggest that antibody assessments alone are not sufficient to identify a vaccine response, and analyses of both humoral and cellular immunity will be important.

Schmidt et al. (May 14, 2021). Cellular Immunity Predominates over Humoral Immunity after the First Dose of COVID-19 Vaccines in Solid Organ Transplant Recipients. Pre-print downloaded May 17 from https://doi.org/10.1101/2021.05.07.21256809