Alliance for Pandemic Preparedness

May 17, 2021

Durability of MRNA-1273-Induced Antibodies against SARS-CoV-2 Variants



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  • [Pre-print, not peer-reviewed] An analysis of sera from participants in the Moderna vaccine trial (n=24) found that most individuals maintained both binding and functional antibodies against the B.1.1.7, B.1.351, P.1, B.1.429, and B.1.526 SARs-CoV-2 variants for 6 months, although at lower levels relative to wildtype and D614G. The B.1.1.7 lineage had little impact on antibody recognition and function, while B.1.351 had a greater effect, ranging from 3 to 15-fold reductions, and the other variants had intermediate impacts. The authors posit that the differential effects of the B.1.351 mutation on antibody response may be due to certain immune pressures that favor mutations like E484K.

Pegu et al. (May 16, 2021). Durability of MRNA-1273-Induced Antibodies against SARS-CoV-2 Variants. Pre-print downloaded May 17 from