May 18, 2021

Decay of Fc-Dependent Antibody Functions after Mild to Moderate COVID-19

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity

• Antibody effector functions associated with opsonization and killing of infected cells declined over time in a cohort of 58 subjects recovering from mild-to-moderate COVID-19. Levels of anti-SARS-CoV-2 spike (S) antibodies with Fcy receptors, S-specific antibody-dependent cellular cytotoxicity (ADCC), and antibody dependent phagocytosis (ADP) declined from the initial peak in samples drawn ~30-60 days post-symptom onset but remained detectable in 94% of subjects when the last samples were collected at a median of 123 days post-symptom onset.

Lee et al. (May 5, 2021). Decay of Fc-Dependent Antibody Functions after Mild to Moderate COVID-19. Cell Reports Medicine. https://doi.org/10.1016/j.xcrm.2021.100296