Alliance for Pandemic Preparedness

May 18, 2021

Extended Interval BNT162b2 Vaccination Enhances Peak Antibody Generation in Older People

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  • [Pre-print, not peer-reviewed] Adults aged >80 years with 11-12 week intervals between doses of the Pfizer-BioNTech vaccine (n=79) had 3.5-fold higher peak titers of anti-SARS-CoV-2 spike antibodies compared to adults >80 given a standard three-week interval between doses (n=68) in a cohort study of in the UK. However, the magnitude of spike-specific T cell responses 2-3 weeks after the second dose was 3.6-fold lower in the extended interval cohort compared to the standard interval cohort.

Parry et al. (May 17, 2021). Extended Interval BNT162b2 Vaccination Enhances Peak Antibody Generation in Older People. Pre-print downloaded May 18 from https://doi.org/10.1101/2021.05.15.21257017