May 20, 2021

Assessment of the Association of Vitamin D Level With SARS-CoV-2 Seropositivity Among Working-Age Adults

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

Keywords (Tags): clinical characteristics

• Low levels of Vitamin D (<20 ng/mL) was not associated with positivity for anti-SARS-CoV-2 IgG antibodies (OR=1.04, 95% CI=0.88-1.22), after adjustment for confounders in a large cohort study of US employees and spouses of Quest Diagnostics (n=18,148). Vitamin D levels were measured prior to the pandemic in 2019 and results were adjusted for age, sex, race/ethnicity, education, body mass index, blood pressure, smoking status, and geographical location. The lack of a significant association with antibody positivity persisted even with a higher cutoff of <30 ng/mL, analysis using Vitamin D levels measured during the pandemic, and with propensity score analyses. 

Li et al. (May 19, 2021). Assessment of the Association of Vitamin D Level With SARS-CoV-2 Seropositivity Among Working-Age Adults. JAMA Network Open. https://doi.org/10.1001/jamanetworkopen.2021.11634