May 25, 2021

SARS-CoV-2 Infection Induces Long-Lived Bone Marrow Plasma Cells in Humans

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity

• Mean anti-SARS-CoV-2 spike IgG antibody titers exhibited a biphasic decay with a rapid decay during the first 4 months followed by a more gradual decline up to 11 months in an analysis of sera from 77 convalescent individuals, most of whom had recovered from mild COVID-19. Analysis of bone marrow aspirates collected at 7-8 months and at 11 months in a subset of participants showed that frequency of spike-specific bone marrow plasma cells (BMPCs) correlated with spike-specific antibody titers, compared to aspirates from healthy controls in which BMPCs were not detected.

Turner et al. (May 24, 2021). SARS-CoV-2 Infection Induces Long-Lived Bone Marrow Plasma Cells in Humans. Nature. https://doi.org/10.1038/s41586-021-03647-4