Alliance for Pandemic Preparedness

May 25, 2021

Symptoms After COVID-19 Vaccination in Patients With Persistent Symptoms After Acute Infection: A Case Series

Category:

Topic:

Keywords (Tags): ,

  • In a case series of 36 participants from the UK with persistent COVID-19 symptoms 8 months after hospitalization, 71% of reported symptoms present prior to vaccination with a COVID-19 vaccine were unchanged a median of 1 month after receiving the first dose. 23% of symptoms had improved, and 6% had worsened. Prior to vaccination, participants had a median of 4 symptoms across multiple organ systems, the most common of which were fatigue (75%)  breathlessness (61%) and insomnia (53%). 72% of participants reported transient systemic effects after vaccination, including fever, myalgia, and headache. No difference in any outcome measure was identified across the vaccines received (Pifzer-BioNTech or Oxford-AstraZeneca).

Arnold et al. (May 25, 2021). Symptoms After COVID-19 Vaccination in Patients With Persistent Symptoms After Acute Infection: A Case Series. Annals of Internal Medicine. https://doi.org/10.7326/M21-1976