May 26, 2021

Association of Circulating Sex Hormones With Inflammation and Disease Severity in Patients With COVID-19

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

Keywords (Tags): clinical characteristics

• Lower testosterone concentrations during hospitalization were associated with increased disease severity, inflammation, and mortality in a cohort of 152 male COVID-19 patients. This association remained after controlling for other known risk factors for severe COVID-19, including age, BMI, comorbidities, smoking, and race. Testosterone concentrations were similar among those who presented with severe illness and those who developed severe illness during their hospital stay, which suggests testosterone may be a biomarker for risk of severe disease. 

Dhindsa et al. (May 25, 2021). Association of Circulating Sex Hormones With Inflammation and Disease Severity in Patients With COVID-19. JAMA Network Open. https://doi.org/10.1001/jamanetworkopen.2021.11398