May 27, 2021

Cellular and Humoral Response after MRNA-1273 SARS-CoV-2 Vaccine in Kidney Transplant Recipients

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immune response, immunity

• Only 35 of 117 (30%) kidney transplant recipients without known prior SARS-CoV-2 infection had a detectable humoral immune response (anti-spike IgG and/or IgM antibodies) to the Moderna vaccine two weeks after the second dose, while 55% had a detectable cellular immune response. Development of both humoral and cellular immune responses was observed in 20% of patients. In total, only 65% presented with any immune response to vaccination. Baseline immunosuppression was associated with a lack of humoral response.

Cucchiari et al. (May 26, 2021). Cellular and Humoral Response after MRNA-1273 SARS-CoV-2 Vaccine in Kidney Transplant Recipients. American Journal of Transplantation. https://doi.org/10.1111/ajt.16701