Alliance for Pandemic Preparedness

May 27, 2021

Post-Vaccination SARS-CoV-2 Infection Risk Factors and Illness Profile in a Prospective Observational Community-Based Case-Control Study

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  • [Pre-print, not peer-reviewed] Breakthrough SARS-CoV-2 infections after at least 14 days following the first dose of the Oxford-AstraZeneca or Pfizer-BioNTech vaccines were less likely among those with healthier lifestyle factors. Findings were based on a case-control study of 2,394 individuals with a breakthrough infection matched 1:1 by age, sex, and other potential confounders to other vaccinated individuals in the UK. Individuals living in the most deprived areas had increased risk of breakthrough infection, as well as older adults aged ≥60 years. Frailty was associated with a 3-fold higher risk of breakthrough infection. In a separate analysis matching individuals with breakthrough infection to a control group of unvaccinated adults with infection, vaccinated individuals reported fewer symptoms and had 64% lower risk of hospitalization.

Antonelli et al. (May 26, 2021). Post-Vaccination SARS-CoV-2 Infection Risk Factors and Illness Profile in a Prospective Observational Community-Based Case-Control Study. Pre-print downloaded May 27 from https://doi.org/10.1101/2021.05.24.21257738