May 28, 2021

E484K as an Innovative Phylogenetic Event for Viral Evolution: Genomic Analysis of the E484K Spike Mutation in SARS-CoV-2 Lineages from Brazil

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): immunity, variants

• Genomic and phylogenetic analyses of SARS-CoV-2 genomes with the E484K mutation sequenced from samples in Brazil in 2020 showed that over 40% of sequenced genomes had this mutation by October 2020 across three distinct lineages (P.1, P.2, and N.9) in four different regions. Modeling of a random set of sequenced genomes suggests that the mutation is under positive selection in lineages in Brazil.

Ferrareze et al. (May 25, 2021). E484K as an Innovative Phylogenetic Event for Viral Evolution: Genomic Analysis of the E484K Spike Mutation in SARS-CoV-2 Lineages from Brazil. Infection, Genetics and Evolution. https://doi.org/10.1016/j.meegid.2021.104941