June 1, 2021

Correlation of Vaccine-Elicited Antibody Levels and Neutralizing Activities against SARS-CoV-2 and Its Variants

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): antibodies, vaccines

• [Pre-print, not peer-reviewed] Analysis of sera from individuals fully vaccinated with the Pfizer-BioNTech (n=30) and Moderna (n=19) vaccines ≥22 days after the second dose showed that neutralizing activity against pseudoviruses bearing mutated spike proteins from variants of concern was detectable in all participants but was reduced by 7-10 fold against the B.1.351 variant. Anti-SARS-CoV-2 IgG antibody levels correlated well with neutralizing titers for the wild-type strain as well as for variants of concern. 

Liu et al. (May 31, 2021). Correlation of Vaccine-Elicited Antibody Levels and Neutralizing Activities against SARS-CoV-2 and Its Variants. Pre-print downloaded Jun 1 from https://doi.org/10.1101/2021.05.31.445871