Alliance for Pandemic Preparedness

June 1, 2021

Distinct Immunological Signatures Discriminate Severe COVID-19 from Non-SARS-CoV-2-Driven Critical Pneumonia

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  • An analysis of the immune response profile of COVID-19 patients suggests that T-cell exhaustion and impaired early antiviral response are characteristic of severe COVID-19 when compared to other causes of severe pneumonia. The authors enrolled participants with either or mild/moderate (n=86) or severe COVID-19 disease (n=35) and participants with other causes of hospital acquired pneumonia (n=25) and analyzed longitudinal samples of peripheral PBMCs using high-resolution flow cytometry. Additionally, the authors identified low circulating Natural Killer T-cell frequencies as a potential predictive biomarker for severe disease.

Kreutmair et al. (May 2021). Distinct Immunological Signatures Discriminate Severe COVID-19 from Non-SARS-CoV-2-Driven Critical Pneumonia. Immunity. https://doi.org/10.1016/j.immuni.2021.05.002