Alliance for Pandemic Preparedness

June 2, 2021

Analysis of SARS-CoV-2 Mutations Reveals Three Types of Temporal Dynamics and One Is Correlated with International Travels

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  • [Pre-print, not peer-reviewed] Analysis of over 1 million SARS-CoV-2 genomes identified 115 non-synonymous mutations estimated to be present in >3% of global COVID-19 cases. COVID-19 cases were identified from 714 country-month combinations from 98 countries. High frequency mutations were defined as frequency changes occurring between a >15% increase and <5% decrease over 2 months, including the D614G mutation; medium frequency mutations were those present in 10% of cases in at least one given month, including the N501Y mutation present in the B.1.1.7 and B.1.351 variants. Levels of high-frequency mutations were found to correlate with international travel patterns.

Arevalo et al. (June 1, 2021). Analysis of SARS-CoV-2 Mutations Reveals Three Types of Temporal Dynamics and One Is Correlated with International Travels. Pre-print downloaded Jun 2 from https://doi.org/10.1101/2021.06.01.446571