Alliance for Pandemic Preparedness

June 3, 2021

Co-Infections, Secondary Infections, and Antimicrobial Use in Patients Hospitalised with COVID-19 during the First Pandemic Wave from the ISARIC WHO CCP-UK Study: A Multicentre, Prospective Cohort Study

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  • Of 1,080 microbiologically confirmed infections in patients hospitalized for COVID-19 between February and June 2020 in the UK, 762 (70.6%) were secondary, occurring >2 days after hospital admission. Among patients hospitalized for COVID-19 during this period and with available data, 37% (13,390 of 36,1456) had received antimicrobials in the community prior to hospital admission, and 85% (39,258 of 46,061) received antimicrobials during inpatient care. Broad-spectrum antimicrobials including carbapenems were more frequently used than carbapenem-sparing alternatives. 

Russell et al. (June 17, 2021). Co-Infections, Secondary Infections, and Antimicrobial Use in Patients Hospitalised with COVID-19 during the First Pandemic Wave from the ISARIC WHO CCP-UK Study: A Multicentre, Prospective Cohort Study. The Lancet Microbe. https://doi.org/10.1016/S2666-5247(21)00090-2