Alliance for Pandemic Preparedness

June 4, 2021

Immunological Dysfunction Persists for 8 Months Following Initial Mild-Moderate SARS-CoV-2 Infection

Category:

Topic:

Keywords (Tags): ,

  • [Pre-print, not peer-reviewed] A prospective cohort study found that persons with persistent symptoms following COVID-19 infection had an elevated diffuse inflammatory cytokine profile at 8 months post SARS-CoV-2 infection, which was not observed in age/gender matched asymptomatic COVID-19 survivors, healthy controls, or persons who survived other human coronaviruses. Additionally, persons with persisting symptoms had a lack of naïve T and B cell reconstitution, suggesting immunological inflammation at a cellular level. The authors hypothesize that this prolonged inflammation and abnormal immune profile may be the underlying cause of symptomologies characterized as “long COVID”.  

Phetsouphanh et al. (June 3, 2021). Immunological Dysfunction Persists for 8 Months Following Initial Mild-Moderate SARS-CoV-2 Infection. Pre-print downloaded Jun 4 from https://doi.org/10.1101/2021.06.01.21257759