Alliance for Pandemic Preparedness

June 7, 2021

Effectiveness of MRNA COVID-19 Vaccines among Employees in an American Healthcare System

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  • [Pre-print, not peer-reviewed] A study of SARS-CoV-2 infections among employees of the Cleveland Clinic Health System found that after adjusting for the slope of the epidemic curve, age, and job type, vaccination was associated with a significantly reduced risk of infection (HR = 0.03), corresponding to a vaccine effectiveness of 97.1%. Vaccine effectiveness was 89.2% at 7 days and 95.0% at 14 days after the first dose. Among 46,866 employees, 28,223 (60%) were vaccinated by the end of the study period, and only 15 (0.7%) of the 2,154 SARS-CoV-2 infections during the study occurred among those who were vaccinated. 

Shrestha et al. (June 5, 2021). Effectiveness of MRNA COVID-19 Vaccines among Employees in an American Healthcare System. Pre-print downloaded Jun 7 from https://doi.org/10.1101/2021.06.02.21258231