June 8, 2021

Association between Previous Infection with SARS CoV-2 and the Risk of Self-Reported Symptoms after MRNA BNT162b2 Vaccination: Data from 3,078 Health Care Workers

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): vaccination

• An online questionnaire among healthcare workers vaccinated with the Pfizer-BioNTech vaccine in Italy (n=3,078) found that participants with prior SARS-CoV-2 infection (n=396) had a 3-fold higher risk of moderate systemic symptoms (MSS) after the first dose, but had a 30% lower risk of symptoms after the second dose. MSS was defined as symptoms that either interfered with daily activities or resulted in time off work. MSS occurred more frequently following the second dose regardless of history of infection. No severe adverse events were reported.

d’Arminio Monforte et al. (May 30, 2021). Association between Previous Infection with SARS CoV-2 and the Risk of Self-Reported Symptoms after MRNA BNT162b2 Vaccination: Data from 3,078 Health Care Workers. EClinicalMedicine. https://doi.org/10.1016/j.eclinm.2021.100914