June 8, 2021

Nanobodies from Camelid Mice and Llamas Neutralize SARS-CoV-2 Variants

Category: Article Summary

Topic: Testing and Treatment

Keywords (Tags): treatment, variants

• Two groups of single-domain antibodies, known as nanobodies, isolated from llamas and genetically engineered mice was identified to possess anti-SARS-CoV-2 receptor binding domain (RBD) neutralizing activity. The first group is able to bind to a region in the RBD largely preserved across SARS-CoV-2 mutations but rarely targeted by human antibodies, while the second group demonstrated high neutralizing activity against variants of concern when expressed as homotrimers.

Xu et al. (June 7, 2021). Nanobodies from Camelid Mice and Llamas Neutralize SARS-CoV-2 Variants. Nature. https://doi.org/10.1038/s41586-021-03676-z