June 9, 2021

Outbreak of SARS-CoV-2 B.1.1.7 Lineage after Vaccination in Long-Term Care Facility, Germany, February-March 2021

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): breakthrough infection, outbreak, vaccine, variant

• A SARS-CoV-2 outbreak in a long-term care facility in Germany resulted in a milder disease course, considerably shorter viral RNA shedding (7.5 vs 31 days), and lower peak viral load in vaccinated residents with breakthrough infection compared to unvaccinated residents. The outbreak involved a sequence-confirmed B.1.1.7 (Alpha) variant and resulted in 16 breakthrough infections in 20 residents who had received the second dose of the Pfizer-BioNTech vaccine within the prior 2 weeks and 4 infections in unvaccinated residents. 

Tober-Lau et al. (June 8, 2021). Outbreak of SARS-CoV-2 B.1.1.7 Lineage after Vaccination in Long-Term Care Facility, Germany, February-March 2021. Emerging Infectious Diseases. https://wwwnc.cdc.gov/eid/article/27/8/21-0887_article