Alliance for Pandemic Preparedness

June 9, 2021

Seroprevalence of SARS-CoV-2 Antibodies Among Rural Healthcare Workers



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  • [Pre-print, not peer-reviewed] In rural healthcare centers in South Dakota, a seroprevalence study revealed that prevalence of anti-SARS-CoV-2 antibodies in healthcare workers at each clinical site was higher than the reported cumulative incidence of COVID-19 in the general population of each respective county. The prevalence of anti-SARS-CoV-2 antibodies among healthcare workers employed at clinics in three rural counties in eastern South Dakota and western Minnesota rose from 0.3% (1 of 336 samples) between May and July 2020 to 15% (35 of 235 samples) between October and December 2020, suggesting that a significant proportion of healthcare workers remained susceptible to COVID-19. In the last round of samples tested, 8 of 35 seropositive individuals did not report a prior COVID-19 diagnosis.

Neises et al. (June 8, 2021). Seroprevalence of SARS-CoV-2 Antibodies Among Rural Healthcare Workers. Pre-print downloaded Jun 9 from