Alliance for Pandemic Preparedness

June 10, 2021

Antibodies Elicited by mRNA-1273 Vaccination Bind More Broadly to the Receptor Binding Domain than Do Those from SARS-CoV-2 Infection

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  • Vaccine-elicited anti-SARS-CoV-2 antibodies in individuals fully vaccinated with the Moderna vaccine in phase 1/2 trials (n=14) were found to target more epitopes within the receptor binding domain (RBD) when compared to individuals with prior infection. Binding of vaccine-elicited antibodies was more broadly distributed across epitopes compared to infection-elicited antibodies within the RBD, which the authors suggest indicates that single mutations in the RBD are less likely to escape neutralizing activity induced by vaccines than by prior infection.

Greaney et al. (June 8, 2021). Antibodies Elicited by mRNA-1273 Vaccination Bind More Broadly to the Receptor Binding Domain than Do Those from SARS-CoV-2 Infection. Science Translational Medicine. https://doi.org/10.1126/scitranslmed.abi9915