June 10, 2021

Clinical and Molecular Characteristics of COVID-19 Patients with Persistent SARS-CoV-2 Infection

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

Keywords (Tags): clinical characteristics, sequelae

• COVID-19 patients with extended viral shedding for >45 days (n=12) had lower levels of inflammatory cytokines/chemokines (IL-2, TNF, and LT-α) compared to an age- and sex-matched cohort of COVID-19 patients in whom viral shedding resolved within 21 days (n=39). Single-cell RNA sequencing from peripheral mononuclear blood cells from a subset of patients showed suppressed T cell responses and reduced expression of ribosomal protein genes in patients with extended viral shedding.

Yang et al. (June 9, 2021). Clinical and Molecular Characteristics of COVID-19 Patients with Persistent SARS-CoV-2 Infection. Nature Communications. https://doi.org/10.1038/s41467-021-23621-y