Alliance for Pandemic Preparedness

June 10, 2021

Highly-Specific Memory B Cells Generation after the 2nd Dose of BNT162b2 Vaccine Compensate for the Decline of Serum Antibodies and Absence of Mucosal IgA

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  • [Pre-print, not peer-reviewed] The Pfizer-BioNTech vaccine only elicited a short-lived mucosal IgA antibody response in a study of 108 vaccinated healthcare workers (HCWs) in Italy without prior infection, with none of the vaccinated HCWs tested for mucosal IgA having a detectable response 2-3 weeks after the second dose. By contrast, the vaccine elicited robust memory B cell responses that were highly specific to SARS-COV-2 up to 3 months after the first dose, including IgA-secreting memory B cells.

Mortari et al. (June 9, 2021). Highly-Specific Memory B Cells Generation after the 2nd Dose of BNT162b2 Vaccine Compensate for the Decline of Serum Antibodies and Absence of Mucosal IgA. Pre-print downloaded Jun 10 from https://doi.org/10.1101/2021.06.08.21258284