Alliance for Pandemic Preparedness

June 11, 2021

Does Reactogenicity after a Second Injection of the BNT162b2 Vaccine Predict Spike IgG Antibody Levels in Healthy Japanese Subjects

Category:

Topic:

Keywords (Tags): ,

  • [Pre-print, not peer-reviewed] A small study of Japanese healthcare workers (N=67) found that reactogenicity to a second dose of the Pfizer-BioNTech vaccine was not a predictor of subsequent IgG antibody levels. The study controlled for age, sex, and IgG levels after the first dose of vaccine. The prevalence of local and systemic reactogenicity was 2.5-times higher after the second dose compared to the first dose, with a higher severity in younger persons, and spike IgG titers increased 16-fold after the second dose.

Takeuchi et al. (June 10, 2021). Does Reactogenicity after a Second Injection of the BNT162b2 Vaccine Predict Spike IgG Antibody Levels in Healthy Japanese Subjects. Pre-print downloaded Jun 11 from https://doi.org/10.1101/2021.06.08.21258444