Alliance for Pandemic Preparedness

June 11, 2021

Dynamic Changes in the Immune Response Correlate with Disease Severity and Outcomes During Infection with SARS-CoV-2

Category:

Topic:

Keywords (Tags):

  • A small, single center study of persons hospitalized with COVID-19 in China (N=74) identified innate and adaptive immunological differences between patients with severe and non-severe disease. Specifically, patients with severe disease had lower baseline lymphocyte counts, higher neutrophil to lymphocyte ratios, and lower eosinophil counts. T-cell, B-cell, and natural killer cells were also lower among those with severe disease. The authors suggest that these results indicate that innate and adaptive immune responses are correlated with COVID-19 disease severity.

Zheng et al. (June 2021). Dynamic Changes in the Immune Response Correlate with Disease Severity and Outcomes During Infection with SARS-CoV-2. Infectious Diseases and Therapy. https://doi.org/10.1007/s40121-021-00458-y