June 14, 2021

COVID-19 Treatment Combinations and Associations with Mortality in a Large Multi-Site Healthcare System

Category: Article Summary

Topic: Testing and Treatment

Keywords (Tags): treatment

• A study conducted between March and July 2020 that assessed the association between COVID-19 mortality and different treatment combinations found that anticoagulation treatment alone was associated with significantly reduced mortality for both patients receiving intensive care and non-intensive care. The four treatment combinations studied were anticoagulation only (OR=0.2), anticoagulation and remdesivir (OR=0.3), anticoagulation and corticosteroids (OR=0.5), and anticoagulation, corticosteroids and remdesivir (OR=0.4). After adjusting for demographic characteristics, clinical characteristics, and all treatment combinations, there was an absolute decrease in the mortality rate by 2.5% between early and late periods of the study. 

Coppock et al. (2021). COVID-19 Treatment Combinations and Associations with Mortality in a Large Multi-Site Healthcare System. PloS One. https://doi.org/10.1371/journal.pone.0252591