June 14, 2021

The SARS-CoV-2 MRNA Vaccine Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity

Category: Article Summary

Topic: Vaccines and Immunity

Keywords (Tags): vaccine breakthrough, variant

• A study of 24 breakthrough SARS-CoV-2 infections among fully vaccinated US Military Health System beneficiaries indicated that most infections (67%) occurred among those without comorbid conditions, 57% reported close contact with a COVID-19 case in the past month, and no case of breakthrough infection resulted in hospitalization. Sequencing from 10 of 13 qPCR-positive specimens indicated the presence of variants of concern or interest including B.1.1.7 (Alpha) (n=2), P.1 (Gamma) (n=1), and B.1.429 (Epsilon) (n=2) in addition to other strains not classified as variants of concern or interest, including B.1.1 (n=1), B.1.1.519 (n=1), B.1.2 (n=2), and B.1.243 (n=1).

Pollett et al. (June 2021). The SARS-CoV-2 MRNA Vaccine Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciab543